Metabesity and Longevity: USA Special Case Study

Metabesity and Longevity: USA Special Case Study” is an 85-page open-access analytical report produced jointly by Aging Analytics Agency and Targeting Metabesity 2019 to examine the links between metabesity, Longevity and the USA’s current health shortfalls, including low health-adjusted life expectancy (“HALE”) and the large gap between HALE and life expectancy, despite its extremely high per-capita healthcare expenditures, and to chart policy recommendations to neutralize this vast health vs wealth deficit.

Metabesity denotes the common metabolic roots behind some of the most prevalent and costly degenerative diseases burdening the USA economy today. Much of biological aging, which is the largest risk factor for such diseases, can be considered as a disintegration of normal metabolic functioning and coordination. This means that the most effective and economic approach to healthcare necessarily involves the prevention of costly chronic diseases by intervening upon their shared metabolic roots as early as possible, to prevent rather than to treat. Fortunately, science has made large leaps and bounds in identifying the common metabolic and aging-related roots to the most prevalent and costly diseases afflicting Americans today – and the tools, techniques and technologies capable of intervening at those roots in order to expend healthspan, and to compress the incidence of such diseases into the final years of life.

As the issue of aging population intensifies, sick care will become increasingly expensive and ineffective. America needs to rapidly deploy a government-led shift from treatment to prevention, and from prevention to precision health, using deep diagnostics and prognostics in combination with biomarkers of aging, metabesity, health and intervention-effectiveness, to delay the onset of disease with as minimal intervention as possible, as early as possible. Seeking synergies between Longevity research, P4 (preventive, personalized, precision and participatory) medicine and Artificial Intelligence has the potential to enable rapid and widespread policy and infrastructural reforms for USA healthcare to quickly boost National Healthy Longevity, but only with sufficient government commitment.

The USA holds the greatest share of the multi-trillion dollar global Longevity economy and the majority share of global Longevity Industry companies and players. It also has one of the highest rates of healthcare expenditure. The USA has all the resources necessary to become a global leader in Longevity, Preventive Medicine and Precision Health, and of National Healthy Longevity, but lacks national prioritization by its federal government, and a strategy to unite the activities of its Longevity Industry, AI, and Preventive Medicine industry ecosystems to work in synergy, rather than in discoordination.

The USA’s low Health-Adjusted Life Expectancy (HALE) and high gap between HALE and unadjusted Life Expectancy is not a scientific problem, it is a policy problem. And it is the specific forms of policy reform that could transform the USA’s current Longevity deficit into an asset, and help the nation leverage its many assets to become a global Longevity hub, that this report seeks to identify. An increase in Healthy Longevity would be of universal benefit for both the American economy and society. It would decrease the burden of the old on the young, create a reinvigorated workforce and consumer market, and have innumerable benefits to the USA economy as a whole, and put the country in a position to become a global Longevity leader, leveraging scientific progress for the betterment of all society.

This special analytical case-study will be updated and extended following the close of the Targeting Metabesity conference on October 16th, 2019, and will feature comprehensive coverage of the conference, summaries of key presentations and talks, major conclusions reached during panel discussions, and the main Longevity policy takeaways from the conference.